Dr. Jin received his B.S. and M. S. in Food Science and Technology at Seoul National University 1996 and 1998, respectively. In 2002 he received Ph. D. degree in Food Science and Bacteriology (minor) at the University of Wisconsin-Madison under the advisement of Prof. Thomas Jeffries. After completing a post-doctoral training under the advisement of Prof. Gregory Stephanopoulos at Massachusetts Institute of Technology, he served as an Assistant Professor in the Department of Food Science and Biotechnology at Sungkyunkwan University in Korea from 2006 to 2008. In August of 2008, he joined the faculty of Food Science and Human Nutrition as an Assistant Professor in Microbial Genomics.
Ph.D., University of Wisconsin, Madison
M.S., Seoul National University, Korea
B.S., Seoul National University, Korea
Metabolic engineering, which draws upon the key engineering principles of integration and quantification, is a platform technology that provides solutions to various biological problems in the context of systems and synthetic biology. In particular, we are interested in developing and applying systematic and combinatorial methods for strain improvement for the production of fuels, chemicals, and nutraceuticals. Also, we would like to extend these methods for studying fundamental biology problems, such as aging and stress response. The overall goals of our research are (1) to develop useful/efficient computational and experimental tools for the dissection of complex metabolic networks in microbial cells, and (2) to create optimal strains for biotechnological processes using these developed tools.
Probing, characterizing, and engineering cellular state through systems and synthetic biology; Metabolic engineering for production of value added products (fuels, chemicals, and nutraceuticals)
FSHN 595 â" Value Added Biotransformation
FSHN 472 - Sanitation of Food Processing
FSHN 471/MCB 434 - Food and Industrial Microbiology
Assistant Professor, Sungkyunkwan University, Korea, 03/01/2006-08/15/2008
Jin, Y.S., Cate, J.H. Model-guided strain improvement: Simultaneous hydrolysis and co-fermentation of cellulosic sugars. Biotechnology Journal 7, 328-329 (2012)
Cha, C., Kim, S.R., Jin, Y.S., Kong, H.J. Tuning structural durability of yeast-encapsulating alginate gel beads with interpenetrating networks for sustained bioethanol production. Biotechnology Bioengineering 109,63-73 (2012)
Lu, C.H., Choi, J.H., Engelmann Moran, N., Jin, Y.S., Erdman, J. Laboratory-scale production of 13C-labeled lycopene and phytoene by bioengineered Escherichia coli. Journal of Agricultural and Food Chemistry 59,9996-10005 (2011)
Kim, J.S., Heo P., Yang. T.J., Lee, K.S., Jin Y.S., Kim, S. K., Shin, D., Kweon, D.H. Bacterial persisters tolerate antibiotics by not producing hydroxyl radicals. Biochemistry Biophysics Research Communication 413,105-10 (2011)
Milne, C.B., Eddy, J.A., Raju, R., Ardekani,S., Kim, P.J., Senger, R. S., Jin, Y.S., Blaschek, H.P., Price, N.D. Metabolic network reconstruction and genome-scale model of butanol-producing strain Clostridium beijerinckii NCIMB 8052 BMC Systems Biology 5:130 (2011)
Ha, S.J., Wei, Q., Kim, S.R., Galazka, J., Cate, J.H., Jin, Y.S. Co-fermentation of cellobiose and galactose by an engineered Saccharomyces cerevisiae. Applied and Environmental Microbiology 77, 5822-5826 (2011)
Ha, S.J., Kim, S.R., Choi J.H., Park, M.S., Jin Y.S. Xylitol does not inhibit xylose fermentation by engineered Saccharomyces cerevisiae expressing xylA as severely as it inhibits xylose isomerase reaction in vitro. Applied Microbiology and Biotechnology (2011)
Ha S.J., Galazka J.M., Rin Kim S., Choi J.H., Yang X., Seo J.H., Louise Glass N., Cate J.H., Jin Y.S. Engineered Saccharomyces cerevisiae capable of simultaneous cellobiose and xylose fermentation. Proceeding of the National Academy of Sciences 108, 504-509 (2011)
Lee, K.S., Hong, M.E., Jung, S.C., Ha, S.J., Yu, B.J., Koo, H.M., Park, S.M., Seo, J.H., Kweon, D.H., Park, J.C., Jin, Y.S. Improved galactose fermentation of Saccharomyces cerevisiae through inverse metabolic engineering. Biotechnology and Bioengineering 108, 621-631 (2011)
Kim, S.R., Lee, K.S., Choi, J.H., Ha, S.J., Kweon, D.H., Seo, J.H., Jin, Y.S. Repeated-batch fermentations of xylose and glucose-xylose mixtures using a respiration-deficient Saccharomyces cerevisiae engineered for xylose metabolism. Journal of Biotechnology 150, 404-407 (2010)
Jung, S.C., Smith, C.L., Lee, K.S., Hong, M.E., Kweon, D.H., Stephanopoulos, G., Jin, Y.S. Restoration of growth phenotypes of Escherichia coli DH5alpha in minimal media through reversal of a point mutation in purB. Applied and Environmental Microbiology 76, 6307-6309 (2010)
Hong, M.E., Lee, K.S., Yu, B.J., Sung, Y.J., Park, S.M., Koo, H.M., Kweon, D.H., Park, J.C., Jin, Y.S. Identification of gene targets eliciting improved alcohol tolerance in Saccharomyces cerevisiae through inverse metabolic engineering. Journal of Biotechnology 149, 52-59 (2010)
Jin, Y.S. and G. Stephanopoulos (2007) Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metab. Eng. 9(4) 337-347.
Jeffries, T.W., I.V. Grigoriev, J. Grimwood, J.M. Laplaza, A. Aerts, A. Salamov, J. Schmutz, E. Lindquist, P. Dehal, H. Shapiro, Y.S. Jin, V. Passoth and P.M. Richardson (2007) Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis. Nat. Biotechnol. 25(3) 319-326.
Alper, H., Y.S. Jin, J.F. Moxley and G. Stephanopoulos (2005) Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metab. Eng. 7(3) 155-64.
Jin, Y.S., H. Alper, Y.T. Yang and G. Stephanopoulos (2005) Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach. Appl. Environ. Microbiol. 71(12) 8249-8256.
Jin, Y.S., J.M. Laplaz, and TW. Jeffries (2004) Saccharomyces cerevisiae engineered for xylose metabolism exhibits a respiratory response. Appl. Environ. Microbiol. 70(11) 6816-25.