Dr. Helferich obtained a B.S. in Nutrition at Ohio State University, where he obtained a B.S. in Nutrition. From there, he attended the University of Maryland and obtained his M.S. in Dairy Science/Nutritional Science. Next, he attended the University of California at Davis and received his Ph.D. in Nutrition. Dr. Helferich continued his training as a NIEHS post-doctoral fellow in Environmental Toxicology, also at UC-Davis. He started his career as an Assistant Professor of Food Science and Human Nutrition at Michigan State University in 1988, and was promoted to Associate Professor in 1994. In 1997, he came to the University of Illinois and was promoted to Professor in 2002. This year, Dr. Helferich is teaching Principles of Nutrition and is the director of the NIH funded Botanical Research Center at UIUC entitled "Botanical Estrogens: Mechanisms, Dose and Target Tissues".
Ph.D., 1984, University of California, Davis
M.S., 1976, University of Maryland, College Park
B.S., 1974, Ohio State University, Columbus
Food safety and toxicology; effect of natural chemicals present in foods on chronic diseases such as breast cancer Dr. Helferich has research interests in the effect of phytochemicals on chronic diseases, and his focus is on the isoflavone genistein from soy, which acts as an estrogen. It is important for the general public to understand the importance of a healthy diet and not rely on chemicals to eliminate their bad eating habits.
FSHN 595 - Nutrition of Food Scientists
FSHN 220 - Principles of Nutrition
Ju, Y.H., Doerge, D.R., and Helferich, W.G., (2008). A dietary supplement for female sexual dysfunction, avlimil, stimulates the growth of estrogen-dependent breast tumors (mcf-7) implanted in ovariectomized athymic nude mice. Food Chem Toxicol. 46(1): p. 310-20. PMID: 17919800
Chang, E.C., Charn, T.H., Park, S.H., Helferich, W.G., Komm, B., Katzenellenbogen, J.A., and Katzenellenbogen, B.S., (2008). Estrogen receptors alpha and beta as determinants of gene expression: Influence of ligand, dose, and chromatin binding. Mol Endocrinol. 22(5): p. 1032-43. PMID: 18258689 PMCID: PMC2366177
Ju, Y.H., Doerge, D.R., Woodling, K.A., Hartman, J.A., Kwak, J., and Helferich, W.G., (2008). Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (mcf-7ca) in vivo. Carcinogenesis. 29(11): p. 2162-8. PMID: 18632754 PMCID: PMC2722859
Jiang, X., Patterson, N.M., Ling, Y., Xie, J., Helferich, W.G., and Shapiro, D.J., (2008). Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells. Endocrinology. 149(11): p. 5366-73. PMID: 18669594 PMCID: PMC2584580
Wang, V.C., Sable, H.J., Ju, Y.H., Allred, C.D., Helferich, W.G., Korol, D.L., and Schantz, S.L., (2008). Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding. Behav Neurosci. 122(4): p. 794-804. PMID: 18729633 NIHMSID: NIHMSID116107
Helferich, W.G., Andrade, J.E., and Hoagland, M.S., (2008). Phytoestrogens and breast cancer: A complex story. Inflammopharmacology. 16(5): p. 219-26. PMID: 18815740
Iwaniec, U.T., Dube, M.G., Boghossian, S., Song, H., Helferich, W.G., Turner, R.T., and Kalra, S.P., (2009). Body mass influences cortical bone mass independent of leptin signaling. Bone. 44(3): p. 404-12. PMID: 19095090 NIHMSID: NIHMSID98145
Legette, L.L., Martin, B.R., Shahnazari, M., Lee, W.H., Helferich, W.G., Qian, J., Waters, D.J., Arabshahi, A., Barnes, S., Welch, J., Bostwick, D.G., and Weaver, C.M., (2009). Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats. J Nutr. 139(10):1908-13. PMID: 19710157 PMCID: PMC2744611 [Available on 2010/10/1]
Zhang, Y., Li, Q.,Wan, HY, Helferich,WG, Wong, MS. (2009). Genistein and a Soy Extract Differentially Affect Three-Dimensional Bone Parameters and Bone-Specific Gene Expression in Ovariectomized Mice. J. Nutr., Dec 2009; 139: 2230 - 2236. PMID: 19793844
Neese, S.L., Wang, V.C., Doerge, D.R., Woodling, K.A., Andrade, J.E., Helferich, W.G., Korol, D.L., and Schantz, S.L., (2010). Impact of dietary genistein and aging on executive function in rats. Neurotoxicol Teratol. 32(2): p. 200-211. PMID: 19945528
Hsu, A., Bray, T.M., Helferich, W.G., Doerge, D.R., and Ho, E., (2010). Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exp. Biol. Med. 2010;235:90-7. PMID: 20404023
Andrade, J. E., Twaddle, N.C., Helferich, W.G. and Doerge, D.R., (2010). Absolute Bioavailability of Isoflavones from Soy Protein Isolate-Containing Food in Female Balb/c Mice. J Agric Food Chem;58:4529-36. PMID: 20225898
Hilakivi-Clarke, L. Andrade, J.E., and Helferich. W.G. (2010). Is Soy Consumption good or bad for the breast? J. Nutr. 140(12):2326S-34S. Epub 2010 Oct 27. PMID: 20980638 PMCID: PMC2981011
De Assis, S., Warri, A., Benitez, C., Helferich, W.G., and Hilakivi-Clarke, L.A., (2011). Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression. Cancer Prev Res. 4(9):1436-48. Epub 2011 Jun 16. PMID: 21680703
Neese, S.L., Bandara,S.B., Doerge, D.R., Helferich, W.G., Korol, D.L., Schantz, S.L. (2011). Effects of multiple daily genestein treatment on executive function in middle-aged rats. Neurotoxicology & Teratology. 34(1):187-95. Epub 2011 Sep 14 PMID: 21945133.
Allred, C.D., K.F. Allred, Y. Ju, S.M. Virant, and W.G. Helferich. (2001) Soy diets containing genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose dependent manner. Cancer Res. 61(13):5045-5050.
Helferich, W.G., C.D. Allred, and Y.H. Ju. (2001) Dietary estrogens and anti-estrogens. In: Food Toxicol., W.G. Helferich and C.K. Winter (eds.), CRC Press, Boca Raton, FL. pp. 37-56.
Ju, Y.H., K.E. Carlson, J. Sun, D. Pathak, B.S. Katzenellenbogen, J.A. Katzenellenbogen, and W.G. Helferich. (2000) Estrogenic effects of extracts from cabbage, fermented cabbage, and acidified brussels sprouts on growth and gene expression of estrogen-dependent human breast cancer (MCF-7) cells. J. Agric. Food Chem. 48(10):4628-4634.
Santell, R.C., N. Kieu, and W.G. Helferich. (2000) Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice. J. Nutr. 130:1665-1669.